Can we achieve biomimetic electrospun scaffolds with gelatin alone?

Introduction: Gelatin is a natural polymer commonly used in biomedical applications combination with other materials due to its high biocompatibility, biodegradability, and similarity collagen, principal protein of the extracellular matrix (ECM). The aim this study was evaluate suitability gelatin as sole material manufacture tissue engineering scaffolds by electrospinning. Methods: electrospun nine different concentrations onto rotating collector resulting scaffold’s mechanical properties, morphology topography were assessed using testing, scanning electron microscopy white light interferometry, respectively. After characterizing scaffolds, effects concentration solvents crosslinking agent statistically evaluated multivariate analysis variance linear regressions. Results: Fiber diameter inter-fiber separation increased significantly when solvents, acetic acid (HAc) dimethyl sulfoxide (DMSO), increased. roughness decreased properties affected DMSO concentration. Immersed crosslinked did not degrade until day 28. manufactured gelatin-based presented comparable many human tissues such trabecular bone, gingiva, nasal periosteum, oesophagus liver tissue. Discussion: This revealed for first time that biomimetic alone can be produced significant number appropriately setting up levels factors their interactions. These findings also extend statistical relationships form would an excellent starting point future research could optimize interactions both traditional statistics machine learning techniques further develop specific